What is Subtree Pruning and Regrafting (SPR)?
We’ve previously discussed the sheer size of tree space. As the number of taxa (or leaves) increases, the number of Continue Reading …
Introduction to Homologs, Orthologs and Paralogs
What is a Homolog? Homolog is a broad term that describes any gene that shares a common evolutionary ancestor with Continue Reading …
Evolutionary Forces, Fitness and Sequence Space
In population genetics, fitness measures the reproductive success of a genotype or phenotype relative to others in the population. Fitness Continue Reading …
What is Genetic Drift?
In evolution not all change is determined by selection, sometimes change happens by chance. Genetic drift is the random change Continue Reading …
Introduction to Sequence Substitution Models
What is a substitution? A substitution is a type of mutation where a single nucleotide base (A,C, G, T) is Continue Reading …
Introduction to the Molecular Clock
In this post we’ll introduce a few key ideas relating to the molecular clock. What is the Molecular Clock? The Continue Reading …
A small break
Taking a small break this month, but keep a look out for future posts where i’ll cover some fundamentals of Continue Reading …
What is a k-mer?
A k-mer is a substring of a biological sequence with length K, where K can be any number. If you Continue Reading …
Coalescent trees and Bugs in a box
Imagine tracing a tree diagram backwards in time, from the tips all the way back to its root. At each Continue Reading …